Y-27632 Dihydrochloride – ROCK Inhibitor | AbMole

Y-27632 Dihydrochloride is a highly selective Rho-associated kinase (ROCK1 and ROCK2) inhibitor, offered by AbMole, and widely used in cell biology and regenerative medicine. It promotes cell survival, enhances stem cell culture viability, and is frequently used to support induced pluripotent stem cell (iPSC) and embryonic stem cell (ESC) workflows.

Y-27632 acts by inhibiting downstream effectors of the Rho signaling pathway, reducing actin-myosin contraction and improving cell adherence and survival under stress conditions.

Applications: 

• iPSC and ESC culture
• ROCK signaling pathway research
• Prevention of apoptosis in dissociated cells
• Cytoskeletal studies and epithelial cell cultures
• Cell reprogramming and cloning efficiency

Description: 

• Chemical Name: Y-27632 dihydrochloride
• CAS Number: 129830-38-2
• Molecular Formula: C14H21N3O·2HCl
• Purity: ≥98% by HPLC
• Soluble in water and DMSO
• Manufactured by AbMole BioScience

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