ArcticZymes Proteinase – Broad-Specificity Endopeptidase for DNA Workflows

ArcticZymes Proteinase is a non-specific endopeptidase derived from an Arctic marine microorganism. With broad substrate specificity and simple heat inactivation, it is an ideal choice for nucleic acid workflows where protein removal is essential.

This enzyme is particularly effective for chromatin disruption, helping to strip away histones and other proteins that hinder nucleic acid accessibility. It efficiently transforms complex or protein-bound nucleic acid samples into naked DNA while preserving RNA integrity and double-stranded DNA stability thanks to its gentle inactivation protocol.

Description: 

ArcticZymes Proteinase is an unspecific endopeptidase originating from an Arctic marine microbial source. It has broad substrate specificity and is easy to inactivate after use.

Histones and other proteins are known to protect nucleic acids from interacting optimally with other DNA binding proteins and enzymes. ArcticZymes Proteinase is ideally suited for transforming chromatin and other dense nucleic acids to naked DNA. The enzyme is easy to heat-inactivate. This allows thermal inactivation at temperatures allowing RNA integrity as well as avoiding dissociation of dsDNA.

• Recombinant Proteinase from ArcticZymes
• Unspecific endopeptidase with broad substrate range
• Transforms chromatin into naked DNA for downstream analysis
• Facilitates nucleic acid accessibility by removing histones and proteins
• Easy thermal inactivation at RNA- and DNA-safe temperatures
• Suitable for workflows in PCR, NGS, DNA clean-up, and chromatin prep

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