M-SAN High-Quality Nuclease (HQ) – Benzonase Alternative for Bioprocessing

M-SAN HQ (Medium-Salt Active Nuclease High Quality) is a bioprocessing-grade endonuclease developed for efficient removal of both single-stranded and double-stranded DNA and RNA under physiological salt conditions commonly used in manufacturing workflows.

Designed as a direct drop-in replacement for Benzonase, M-SAN HQ enables you to upgrade your process without modifying buffers, salt concentrations, or protocols. This high-purity enzyme supports applications in cell therapy production, AAV manufacturing, vaccine processing, and other regulated biomanufacturing environments.

Description: 

M-SAN HQ is the latest addition to our high salt tolerance nucleases portfolio. The biochemical properties of the SAN family of nucleases make them ideal for multiple bioprocessing and biomanufacturing workflows.

M-SAN HQ has been developed to offer the optimal solution for removal of nucleic acids at the near-physiological conditions used in many bioprocessing and biomanufacturing work?ows. This novel, nonspeci?c endonuclease is active over a broad pH range and displays optimum activity at salt concentrations around 175 mM

• High-quality nuclease for DNA and RNA removal
• Active at physiological/medium salt concentrations
• Supports bioprocessing and GMP-like workflows
• Drop-in Benzonase replacement—no protocol changes needed
• Removes ssDNA, dsDNA, and RNA efficiently
• Suitable for AAV, vaccine, and recombinant protein production

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