Salt Active Nuclease – High Quality, Bioprocessing Grade for DNA/RNA Removal

Salt Active Nuclease High Quality (HQ) is a bioprocessing-grade enzyme engineered for the effective removal of single- and double-stranded DNA and RNA under high-salt conditions, such as those commonly used in AAV, vaccine, and recombinant protein manufacturing.

This high-purity nuclease offers robust activity in challenging buffer environments and is ideal for reducing host cell DNA in downstream processing. It is widely used in GMP-compatible biomanufacturing processes where enzyme quality and consistency are essential.

Description: 

SAN High Quality (Bioprocessing grade) is the ultimate solution for efficient removal of nucleic acids in manufacturing and bioprocessing workflows. This nonspecific, recombinant endonuclease has optimum activity at high salt concentrations, which can improve efficiency and yield in various workflows.

Salt is an important component of various purification schemes. The presence of salt can minimize aggregation, increase target solubility and improve target yield. High salt enables contaminating DNA to dissociate from associated proteins and become available for degradation. SAN High Quality is highly compatible with the use of high salt conditions.

• High-quality Salt Active Nuclease for bioprocessing applications
• Removes both ssDNA and dsDNA, as well as RNA
• Active in high-salt buffers typical of downstream manufacturing
• Supports AAV, vaccine, and biologics production
• Bioprocessing-grade—tested for purity and performance
• Compatible with GMP-like environments

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