CleanCap® OVA mRNA

CleanCap^®Ovalbumin mRNA

Ovalbumin (OVA) is a member of the serpin superfamily and the predominant glycoprotein found in egg whites. It is a commonly used antigen for immunization and biochemical studies and is an established model allergen for airway hyper-responsiveness.

This mRNA is capped using CleanCap™, TriLink’s proprietary co-transcriptional capping method, which results in the naturally occurring Cap 1 structure with high capping efficiency. It is polyadenylated and optimized for mammalian systems. It mimics a fully processed mature mRNA.

TriLink offers both unmodified and 5-methoxyuridine modified OVA mRNA. Exogenous unmodified mRNA activates the innate immune system and production of cytokines, which will influence the overall induced immune response. mRNA modified with 5-methoxyuridine reduces this effect.